The Role of Neuropsychological Assessment in the Detection of Early Symptoms in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (ftdp-17)
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چکیده
Frontotemporal dementia and parkinsonism linked to chromosome 17 is a rare variant of frontotemporal dementia, characterized by behavioral, cognitive and motor dysfunctions. The onset of the disease is variable. However, cognitive and behavioral changes usually precede motor symptoms. Early Background: THE ROLE OF NEUROPSYCHOLOGICAL ASSESSMENT IN THE DETECTION OF EARLY SYMPTOMS IN FRONTOTEMPORAL DEMENTIA AND PARKINSONISM LINKED TO CHROMOSOME 17 (FTDP-17) Emilia J. Sitek, Anna Barczak, Ewa Narożańska, Małgorzata Chodakowska-Żebrowska, Barbara Jasińska-Myga, Bogna Brockhuis, Mariusz Berdyński, Dariusz Wieczorek, Cezary Żekanowski, Seweryna Konieczna, Maria Barcikowska, Zbigniew K. Wszołek, Jarosław Sławek 1 Department of Neurology, St. Adalbert Hospital, Gdansk, Poland 2 Department of Neurological and Psychiatric Nursing, Medical University of Gdansk, Gdansk, Poland 3 Department of Neurodegenerative Diseases, Neurology Clinic, MSWiA Hospital, Warsaw, Poland 4 Department of Neurology, Medical University of Silesia, Katowice, Poland 5 Department of Nuclear Medicine, Medical University of Gdansk, Gdansk, Poland 6 Department of Neurodegenerative Disorders, Mossakowski Medical Research Center, Polish Academy of Sciences, Warsaw, Poland 7 Department of Rehabilitation, Medical University of Gdansk, Gdansk, Poland 8 Department of Developmental Neurology, Medical University of Gdansk, Gdansk, Poland 9 Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA CASE STUDY ACTA Vol. 9, No. 2, 2011, 209-226
منابع مشابه
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) Authors: Doctors
Keywords Disease name Excluded diseases Diagnosis criteria / definition Differential diagnosis Frequency Clinical description Laboratory findings Management including treatment Etiology Diagnostic methods Genetic counseling Keywords References Abstract Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant neurodegenerative disorder caused by mutatio...
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BACKGROUND Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is associated with mutations in the Microtubule-Associated Protein Tau(MAPT) gene or the Progranulin(PGRN) gene. MAPT mutations lead to widespread deposition of hyperphosphorylated tau protein (FTDP-17T). PGRN mutations are associated with ubiquitin- and TDP-43-positive inclusions in the frontotemporal cortex,...
متن کاملPrion disease resembling frontotemporal dementia and parkinsonism linked to chromosome 17.
OBJECTIVE To compare the clinical features of a familial prion disease with those of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). BACKGROUND Prion diseases are not usually considered in the differential diagnosis of FTDP-17, since familial Creutzfeldt-Jakob disease (CJD), the most common inherited prion disease, often manifests as a rapidly progressive dementia....
متن کاملRefining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN).
Frontotemporal dementia with parkinsonism (FTDP) is a major neurodegenerative syndrome, particularly for those with symptoms beginning before age 65 years. A spectrum of degenerative disorders can present as sporadic or familial FTDP. Mutations in the gene encoding the microtubule-associated protein tau (MAPT; OMIM +157140) on chromosome 17 have been found in many kindreds with familial FTDP. S...
متن کاملNEUROLOGICAL REVIEW Refining Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17 Introducing FTDP-17 (MAPT) and FTDP-17 (PGRN)
F rontotemporal dementia with parkinsonism (FTDP) is a major neurodegenerative syndrome, particularly for those with symptoms beginning before age 65 years. A spectrum of degenerative disorders can present as sporadic or familial FTDP. Mutations in the gene encoding the microtubule-associated protein tau (MAPT; OMIM 157140) on chromosome 17 have been found in many kindreds with familial FTDP. S...
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